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Systems Club III – Light Sheet Microscopy

Deeper Insights: Exploring LSM in Combination with Tissue Clearing

July 19, 2023 @ 2:00 pm 7:00 pm

Light Sheet Microscopy (LSM) allows revolutionizing high-speed, high-resolution imaging and reduced photo-toxicity, proving invaluable in whole-organ and whole-organism imaging. The combined power of LSM with tissue clearing now offers unparalleled views of intact organ structures, fostering comprehensive investigations and rich insights into the cellular landscape.
The Systems Club is delighted to host an event centering on this remarkable synergy. We will explore the principles of LSM, focusing on its feature: the illumination of thin sections of samples. A spotlight will be on tissue clearing, a process that removes light-scattering elements from tissues, enabling the light to penetrate deeper and offer high-throughput imaging of intact organs or organisms.

The hands-on demonstration will guide you through a typical LSM setup, highlighting the use of tissue clearing in this context. As part of the session, the latest software tools, ClearMap and CellFinder, which facilitate an unbiased, high-throughput analysis of neuronal activity in the whole mouse brain, will be presented. To aid those with limited programming experience, a user-friendly graphical interface to streamline these analysis tools was developed and will be also introduced.
Join us on this journey, as we untangle the complexities of LSM and tissue clearing, and open up new possibilities for in-depth hollistic exploration.

2 – 3:30PM: Welcome, Presentations and Discussion Round on:

  • Tissue Clearing and Light Sheet Microscopy: Implications in Neuroscience
  • Computational Analysis of Light Sheet Microscopy data

3:30 – 4:30PM: Lab Tour

  • Light Sheet Microscopy and Tissue Clearing

While you are waiting for your next tour slot or if you are already done, you can start joining the catering and open discussion .

4:30PM – Open End: Discussion with Catering and Wine


Registration is available after login – if you do not have an ISyN-Account yet, create one, using the “Become a member”-Button in the top.

After you registered for this event, you will get an e-mail asking you for some more details regarding e.g. tours you’d like to participate in.

Registrations are closed for this event

Lena Fröhlich

Biozentrum 1

Hanns-Dieter-Hüsch-Weg 15
Mainz, RLP 55128 Germany